Search results for " transcription" in Articles / App Notes
Article
A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
FHD=first human dose, FRD=first registration dose, PCR=polymerase chain reaction, qPCR=quantitative polymerase chain reaction, MCB=master cell bank, RT-PCR=reverse transcription polymerase chain react…
Article
mRNA: The Messenger - mRNA Synthesis
Join us for part 3 of mRNA: the messenger, where we discuss key considerations for the synthesis of RNA molecules, including optimizing the mRNA template design, in vitro transcription, and process pa…
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Regulatory Requirements for Safe and Efficient Biologic Drug Development
STEVE
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Steven Lynn, Executive Vice-President, Pharmaceuticals, Regulatory Compliance Associates, shares insight into regulatory require…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
In the case of mRNA vaccines, the transcription step is already completed, so the cells that take up the mRNA only need to transcribe the mRNA sequence into the protein-of-interest. Viral vector-based…
Article
Top Tips for Successful Development of Antibody Chromatography Processes
In this interview, Jakob Liderfelt, Product Manager at Cytiva, discusses main challenges faced during chromatography process development for mAbs and mAb variants such as fragments and bispecific a…
Article
Discovering the unknown: How does in silico process development change PD scientists’ work?
In silico process development for chromatography is a paradigm-shifting approach that redefines the routine work of process development scientists. But what does it actually mean to perfor…
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Report from the 6th International HTPD Conference
Spencer McMinn from Merck discussed the need to improve the in vitro transcription (IVT) step to be able to quickly develop new mRNA type of vaccines. McMinn presented how integration of algorithmic o…
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Top challenges in recombinant protein purification process development
In this video, Emma Lind, Product Manager for Chromatography Resins at Cytiva answers questions from BioPharm International about the challenges faced by process developers working with recombi…
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Manufacturing mRNA for research and beyond
This eBook guides you in the practical aspects of setting up an mRNA research laboratory. Get insights on methods, materials, and workflows for mRNA synthesis and scale up.
Explore the mRNA…
Article
Optimizing your Cell Culture Process to Improve Productivity
Cell Culture Process
In this video, Mary Szorik and Alicia Elwood at Cytiva, discuss the rationale for cell culture and analytical testing as well as the types of tests that can lead …