Search results for "perfusion"
Achieving Process Balance with Perfusion Bioreactors
With rising pressure to reduce costs and streamline bioprocess development, biopharmaceutical manufacturers are exploring the application of perfusion to a wider selection of biomolecules. “Perfus…
Perfusion in the 21st Century
Now, improved continuous culture technologies such as perfusion are on the rise, as biosimilar manufacturers look for new ways to cut costs while increasing quality and productivity. With perfusio…
Highly efficient inoculum propagation in perfusion culture using WAVE Bioreactor™ systems
Fed-batch cultures were inoculated with cells propagated in either batch or perfusion cultures. All cultures were grown in disposable Cellbag™ bioreactors using the WAVE Bioreactor system. Cell concen…
Perfusion Media Development for Scalable Processes
The nutrient-rich but balanced media should be designed to support very low cell-specific perfusion rates (CSPR) that minimize media consumption while maximizing viable cell days and productivities. O…
Perfusion Culture Using TFF or ATF as Cell Retention Method
Compared with batch or fed-batch processes, perfusion processes also allow cells to be maintained in exponential growth phase for an extended period of time and reach higher viable cell densities. …
Repurposing Fed-Batch Media and Feeds for Highly Productive CHO Cell Perfusion Processes
Here, they show that they can obtain culture media that successfully support perfusion cultures in bioreactors at cell-specific perfusion rates (CSPR) below 25 pL/cell/day. High productivities and fav…
Developing a Continuous Large-Scale Perfusion Cell Culture Process
This article explores the key benefits of perfusion processes.
Cytiva Introduces the Xcellerex Automated Perfusion System
16, 2020 that it is launching the Xcellerex Automated Perfusion System (APS), a device aimed at simplifying processes and reducing risks when intensifying upstream operations. Integrated with Cyti…
Development Strategies for High-Performing Perfusion Media
In this webinar, an expert describes a structured approach for developing a perfusion medium from a combination of commercially available medium and feeds. Learn how this methodology can be applied to…
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAb at Large Scale
Perfusion continues to be one such operating mode that lends itself to adding benefit at the manufacturing scale while adding complexity to the small-scale approach.