Search results for " mass transfer"

Article Being Thorough When Transferring Technology
Blackwell (Windshire): As a chemical engineer, I think first about mass transfer and heat transfer limitations. Fortunately, some of these can be anticipated and planned for in advance. This requires …

Article Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Prerequisites for modeling With the recent advancement of efficient numerical methods, it is feasible to create a complex and detailed mechanistic model that is capable of describing mass transfer

Article Implications of Cell Culture Conditions on Protein Glycosylation
The authors present a review of the techniques commonly used for glycosylation analysis. By Michiel E. Ultee, PhD, Dr. Richard Easton This article reviews the implications of cell-culture co…

Article Analysis of Glycosylation in Biosimilars
A step-wise process is used to characterize glycans and understand the functioning of a molecule for biosimilar development. The structures of protein drugs such as monoclonal antibodies are mad…

Article Cell-Culture Advances Test Bioreactor Performance Models
In addition, Smith notes there is a need for improved mass transfer performance with reduced shear in single-use bioreactors. “As cultures become more intensified, the need for oxygen transfer increas…

Article Single-use Bioreactors Have Reached the Big Time
“When considering the workflow and objectives of running bioreactors, recent developments have focused on reducing complexity, improving mixing to achieve higher volumetric mass transfer coefficients …

Article Fluid Handling in Biopharma Facilities
Industry experts discuss challenges, trends, and innovations in fluid handling. By Susan Haigney Contamination prevention in biopharmaceutical manufacturing is crucial, and the proper handling…

Article Understanding Validation and Technical Transfer, Part 3
Understanding Validation and Technical Transfer, Part 3 Validation ensures safe and effective biologic products that benefit the patients whose health and wellbeing depend on the therapies. Part 1 |…

Article Re-use of Protein A Resin: Fouling and Economics
Large pores enable rapid mass transfer but also reduce the surface area available for the protein to bind, resulting in lower equilibrium capacities. High ligand densities result in high capacities bu…

Article Automated Concentration and Diafiltration of Multiple siRNA Samples
A team of scientists collaborated on a project to transfer a conventional manual concentration/diafiltration process for siRNA production.  ABSTRACT The use of small-interf…

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