Search results for " Mab"

Article Modeling the Degradation of mAb Therapeutics
It can, either directly or indirectly, affect mAbs’ biological activity as well as toxicity (4).  The instabilities associated with mAbs can be broadly classified as either physical or chemical…

Article Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
A study by BioProcess Technology Consultants estimated that approximately 70 mAb products could be on the market by 2020, which could be associated with up to £125 billion in sales (1). Purifying …

Article mAbs to Watch in 2016
Although the pharmaceutical manufacturers developing these mAbs will likely seek various indications for their products, the preliminary indications include treatments for various cancers, multiple sc…

Article Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Enormous success achieved with mAbs can be attributed to their distinctive beneficial properties and advantages, which include high binding specificity and affinity, availability of humanized forms th…

Article Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
To address this gap, strategies for improving mAb manufacturing productivity by optimizing powder and liquid buffer and media prep process flow are worth considering. When combined with innovative new…

Poster Modes of controlling charge variant distribution in Mab production
Charge variant distribution is a critical quality attribute for MAbs and is therefore of interest to monitor and control during the production process. In this study, we investigated the effects of ce…

Article Evaluation of Fibro PrismA for Scalable Single-Use mAb Purification
Bayer worked with Cytiva to evaluate a fiber-based alternative, Fibro PrismA, to determine its potential as a truly single-use mAb capture technology. The team assessed scalability from lab- to proces…

Article Strategies and Emerging Technologies for mAb Capture
In this webinar you will learn: • Strategies and emerging technologies for intensifying the mAb capture step • How the design of your upstream mode may determine your optimal downstream soluti…

Article Integrated Semi-Continuous Process for mAb Production
In brief, the mAb process consists of perfusion cell culture, continuous capture chromatography, viral inactivation (VI), post VI filtration, batch polishing chromatography, and a final pH adjustment …

Article Get to know: mAb variants - eLearning
The diversity of antibody variants in the biotherapeutics pipeline are increasing with a growing interest for molecules like antibody fragments and bispecific antibodies (bsAbs). Cytiva has p…

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