Search results for " Mab" in Articles / App Notes

Article Modeling the Degradation of mAb Therapeutics
It can, either directly or indirectly, affect mAbs’ biological activity as well as toxicity (4).  The instabilities associated with mAbs can be broadly classified as either physical or chemical…

Article Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
A study by BioProcess Technology Consultants estimated that approximately 70 mAb products could be on the market by 2020, which could be associated with up to £125 billion in sales (1). Purifying …

Article mAbs to Watch in 2016
Although the pharmaceutical manufacturers developing these mAbs will likely seek various indications for their products, the preliminary indications include treatments for various cancers, multiple sc…

Article Developing a mAb aggregate removal step by high throughput process development
Traditionally, MAbs are purified in a three-step process. First, the target is captured by chromatography with Protein A media, and two subsequent polishing steps are then performed according to a var…

Article Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Enormous success achieved with mAbs can be attributed to their distinctive beneficial properties and advantages, which include high binding specificity and affinity, availability of humanized forms th…

Article Faster scale-up of a two-step MAb process with AxiChrom™ columns and ReadyToProcess™ solutions
The addition of readyto-use solutions to the upstream/downstream process significantly shortens the time-to-clinic journey for MAbs. Scaling up with AxiChrom columns In the scale-up describe…

Article Rapid process development for the purification of a MAb using ÄKTA™ avant 25
Despite the challenging nature of the feed studied, high yield and purity of the target MAb was achieved. Introduction Time and flexibility are essential in process development of purification…

Article Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
To address this gap, strategies for improving mAb manufacturing productivity by optimizing powder and liquid buffer and media prep process flow are worth considering. When combined with innovative new…

Article High-throughput screening methods to speed MAb process development
Improved methods of process development and ready-to-use purification solutions are already minimizing the impact of many laborious tasks in MAb manufacturing. Eliminating tasks such as column pac…

Article Integrated Semi-Continuous Process for mAb Production
In brief, the mAb process consists of perfusion cell culture, continuous capture chromatography, viral inactivation (VI), post VI filtration, batch polishing chromatography, and a final pH adjustment …

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