Search results for " Mab" in Posters

Poster Modes of controlling charge variant distribution in Mab production
Charge variant distribution is a critical quality attribute for MAbs and is therefore of interest to monitor and control during the production process. In this study, we investigated the effects of ce…

Poster Multimodal chromatography media to resolve purification platform challenges of ‘tricky’ MAbs
Designing a robust polishing step, however, requires process optimization, in which it is crucial to also consider MAb stability. This poster describes the screening and optimization of conditions for…

Poster Designing a continuous three-step MAb purification process
Here, these two technologies were evaluated in a continuous three-step chromatography purification process for a MAb.

Poster Performance of a fast Surface Plasmon Resonance based MAb quantification method
In this work we show how Surface Plasmon Resonance (SPR) can be used for MAb quantification.

Poster Displacement Chromatography for mAb Charge Separation
Monoclonal antibodies (mAbs) are large proteins susceptible to several post translational modifications (PTMs) that might cause charge heterogeneity. In the production of biosimilars these modificat…

Poster Optimizing dynamic binding capacity and aggregate clearance in an mAb polishing step
Capto™ S ImpAct is a strong cation exchange (CIEX) chromatography medium (resin) designed for monoclonal antibody (MAb) polishing steps. In this study, optimization of binding conditions targeting h…

Poster In-line conditioning using ready-made stock solutions in a mAb process step
Buffer preparation in the biopharmaceutical industry can be challenging. One trend is in-line dilution of buffer concentrates to reduce the floor space for buffer preparation/storage as well as to e…

Poster Integration of continuous upstream and downstream operations in mAb production
In this case study, we demonstrate the feasibility of integrated upstream and downstream mAb processing performed in a continuous manner. The developed process shows a performance equivalent to tradit…

Poster Purification platform challenges and strategies for handling of "tricky" MAbs
In the work presented here, capture using high-capacity protein A medium (resin) was followed by polishing using a novel cation exchange chromatography medium.

Poster Mab polishing using a new multimodal anion exchanger
Multimodal chromatography has proven to be a powerful tool for solving difficult separation challenges, one of them being aggregate removal while maintaining high yields. To address theses chall…

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