Search results for " mAb aggregate screening"

Article Predicting Progress in Protein Aggregation
Techniques to enable the design and formulation of stable, protein-based therapeutics. In silico analysis and the evaluation of formulability, aided by new analytical tools such as hydrogen deut…

Article Developing a mAb aggregate removal step by high throughput process development
High throughput process development allows rapid screening of chromatographic parameters. By Gustav Rodrigo and Kristina Nilsson-Välimaa ABSTRACT This article presents a case study ill…

Poster Rapid screening of antibody aggregates and protein impurities using short gel filtration columns
Purification of antibodies often generates dimers and higher aggregated forms and during optimization of purification protocols, many samples may need to be analyzed for aggregate content.  Gel f…

Article Polishing of monoclonal antibodies using Capto adhere ImpRes in bind and elute mode
This application note describes a study where the binding capacity for MAbs and the efficiency in the clearance of impurities using Capto adhere ImpRes in bind/elute (B/E) mode was evaluated. For a …

Article Polishing of Monoclonal Antibodies using Capto™ MMC ImpRes in Bind and Elute Mode
A rapid procedure to establish a robust second step in bind/elute (B/E) mode for the purification of a MAb using Capto MMC ImpRes has been developed. This study presents results from optimization …

Article Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Optimization of each phase in a chromatographic cycle has a positive impact on productivity. By Anna Grönberg An important area of focus for the biopharma industry is the elucidation and dev…

Article Addressing the challenges in downstream processing today and tomorrow
Newer classes of biotherapies will require innovations in processing technology. By Glen R. Bolton, Bernard N. Violand, Richard S. Wright, Shujun Sun, Khurram M. Sunasara, Kathleen Watson, Johna…

Article Preclinical Evaluation of Product Related Impurities and Variants
Preclinical Evaluation of Product Related Impurities and Variants The approaches for sample preparation of preclinical evaluation of safety and efficacy are addressed taking into consideration the s…

Article Impact of Media Components on CQAs of Monoclonal Antibodies
The authors review how media components modulate the quality of monoclonal antibody products.  By Anurag Rathore, Rajinder Kaur, Dipankar Borgayari  Recombinant protein products have…

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