Search results for " antibody fragment" in Articles / App Notes

Article Witnessing Major Growth in Next-Generation Antibodies
The global market for next-generation antibodies, including antibody drug conjugates (ADCs), engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar ant…

Article Antibody Production in Microbial Hosts
Therapeutic mAbs and their derivatives—such as antibody fragments (Fab), single-chain Fv (scFv), and diabodies—represent the fastest-growing class of approved therapeutic proteins because of their hig…

Article Single-Domain Antibodies for Brain Targeting
Smaller recombinant antibody fragments as single-domain antibodies (sdAbs) are emerging as credible alternatives because of their target specificity, high affinity, and cost-effective recombinant prod…

Article Chromatography for the Diversified Antibody Pipeline
Jeanne Linke Northrop:How is Cytiva addressing the changing needs and conditions for purifying antibody fragments and bispecific antibodies? Eva Helding: I believe we are trying to address t…

Article Antibody Fragments and Their Purification by Protein L Affinity Chromatography
A majority of such molecules are monoclonal antibodies; however, many new entities are antibody fragments. Due to their structural, physiological, and pharmacological properties, antibody fragments of…

Article Top Tips for Successful Development of Antibody Chromatography Processes
In this interview, Jakob Liderfelt, Product Manager at Cytiva, discusses main challenges faced during chromatography process development for mAbs and mAb variants such as fragments and bispecific a…

Article Evolution of the Monoclonal Antibody Purification Platform
The authors discuss the evolution of the purification platform for manufacturing of mAb therapeutics. Monoclonal antibodies (mAb) increasingly form the majority share of the product pipeline…

Article Defining Critical Quality Attributes for Monoclonal Antibody Therapeutic Products
An approach for establishing the CQAs of a mAb product by evaluating impact and uncertainty during risk assessment. A critical quality attribute (CQA) has been defined as “a physical, chemical, …

Article A Platform Approach to Purification of Antibody Fragments
Here, we present affinity chromatography resins that offer the possibility of a platform approach to the purification of the majority of antibody fragments. The described BioProcess™ resins offer high…

Article Resolving a bottleneck in screening and characterization of recombinant antibody fragments using Biacore 4000
Biacore 4000 equipped with Biacore 4000 Antibody Extension Package has been used for efficient screening and characterization of antibody fragments for diagnostic purposes. Ten 96-well plates containi…

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