Search results for " Hydrophobic interaction chromatogr…"

Poster A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
This poster presents a newly designed, high-capacity Protein A resin, MabSelect™ PrismA, which offers alkali stability on par with ion exchange and hydrophobic interaction chromatography resins, enabl…

Article Evolution of the Monoclonal Antibody Purification Platform
This can result in a different selectivity than what is offered by traditional ion-exchange or hydrophobic interaction chromatography, thus offering a larger range of ionic strength and pH under which…

Article Development of Purification for Challenging Fc-Fusion Proteins
…olishing process that incorporates flow-through strategy in polishing steps using cation exchange or hydrophobic interaction chromatography. As tested on three Fc-fusion proteins, this p…

Article Challenges of Protein Aggregation During Purification
Careful selection of downstream processing conditions is a must. Sep 1, 2014 By: Cynthia Challener, PhD BioPharm International Volume 27, Issue 9, pp. 32-35  Removal of protein a…

Article SEC in the Modern Downstream Purification Process
Mar 01, 2015 By R. Christopher Manzari, J. Kevin O'Donnell BioPharm International Volume 3, Issue 28 Since the introduction of commercial chromatography resins approximately six de…

Article Enhancing Resins Addresses Purification Concerns
Deorkar notes that hydrophobic interaction chromatography (HIC) and anion exchange (AEX) chromatography can be used, but careful optimization of conditions is required to be applicable for large-scale…

Article Impurity Testing of Biologic Drug Products
Process-related variants can be identified, quantified, and differentiated from process-related impurities of cellular origin via techniques such as SEC–HPLC, hydrophobic interaction chromatography (H…

Article Tackling Analytical Method Development for ADCs
Feb 01, 2015 By Cynthia Challener, PhD BioPharm International Volume 28, Issue 2 The targeted therapy possible with antibody-drug conjugates (ADCs) makes them an attractive class of …

Article Addressing the Challenges in Downstream Processing Today and Tomorrow
This unwanted modification required an extra process step using hydrophobic interaction chromatography (HIC) to separate these modified molecules from the desired product. E. coli expression often yie…

Article Modeling the Degradation of mAb Therapeutics
Modeling the Degradation of mAb Therapeutics Kinetic models can be used to study aggregation and fragmentation to help ensure stability. By Anurag S. Rathore, Rohit Bansal …

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