Search results for " preparative"

Article Make buffer preparation more time and cost efficient with inline conditioning
Simplify Buffer Preparation The volume and number of buffers for a typical downstream process can be considerable. Preparation of these buffers is a challenge that in-line conditioning can …

Article Automated In-Line Buffer Preparation from Ready-Made Stock Solutions in a mAb Process Step
Buffer preparation is both time-and space-consuming and can easily become a challenge in biomanufacturing. This application note describes a lean approach to buffer preparation by implementing in-li…

Poster Buffer plate preparation using ÄKTA™ avant system and BufferPro tool
Manual buffer preparation for high-throughput process development (HTPD) requires a lot of effort as the number of different buffer conditions is large. A method was developed for automatic buffer p…

Article Can You Trust a Machine for Downstream Bioprocess Buffer Preparation?
There is a limit to how many stainless-steel tanks you can squeeze into a biomanufacturing facility. Still, resource-intensive buffer preparation has received little attention in biomanufacturing. S…

Poster Scaling In-Line Buffer Preparation from Process Development to Manufacturing
Preparing buffers for large-scale chromatography requires significant resources: time, money, and storage space. Inline conditioning (IC) is one possible way to address these challenges. At the same t…

Article

Tip Urea and protein preparation
To avoid modification of proteins, never heat a sample after adding urea. Elevated temperatures cause urea to hydrolyze to isocyanate, which modifies proteins by carbamylation. When a sample contain…

Article Prepare for an FDA Bioburden Inspection
Not sure how to best approach a bioburden problem when an FDA inspection is imminent? Anastasia Lolas, former FDA Biologics License Application (BLA) reviewer and inspector focusing on microbiology, s…

Article Prepare for an FDA Bioburden Inspection
Even with effective prevention, bioburden incidents can occur. A best-practices response will not only help you be prepared for any upcoming FDA inspection, it may also yield valuable insights to help…

Article Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Seidel-Morgenstern, “Modeling and Model Parameters,” in Preparative Chromatography, (Wiley-VCH verlag GmbH & Co. KgaA, 2nd ed., 2012), pp. 321–424. 3. V. Kumar et al., J. Chromatogr. A 1426, 1…

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