Search results for " chemically defined media" in Articles / App Notes

Article A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
Data acquired from osmolality, glucose, and folic acid tests provides useful information for the specific identification of cell-culture media. By Satish Mallya, Benjamin Lay, Lihong McAleer, Alexa…

Article Impact of Media Components on CQAs of Monoclonal Antibodies
Synthetic or chemically defined media are prepared by adding defined concentration of nutrients (both organic and inorganic) such as vitamins, salts, trace elements, carbohydrates, and cofactors. Esta…

Article An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
Testing product and process intermediates alone is helpful, but does not provide a complete solution to viral safety. This article proposes integrated solutions for systemic and proactive viral risk m…

Article What’s in your media? How costly is variability of cell culture media to your manufacturing process?
We noticed that with chemically defined medias there are between 20 to 100 different components. We use the finest raw materials we can find compendial grade, which are 99.5% pure. However, if there a…

Article Use of Multivariate Data Analysis in Bioprocessing
In this work, chemometric tools were used to rapidly monitor compositional changes in the chemically defined media, and the authors concluded that significant chemical changes in terms of cysteine/cys…

Article QbD and PAT in Upstream and Downstream Processing
To gain perspective on the implementation of quality by design (QbD) and process analytical technology (PAT) in biopharmaceutical processing, BioPharm International spoke with Clinton Weber, as…

Article Regulatory Challenges in the QbD Paradigm
The authors demonstrate how an integrated model is helping to achieve regulatory flexibility. This article is part of a special section on biopharmaceutical trends. With the dawn of the 2…

Article Eliminating Residual Impurities Starts with a Strategic Plan
Eliminating Residual Impurities Starts with a Strategic Plan Identifying the source, assessing the risk, and removing residual impurities requires a strategic approach. By Cynthia A. Ch…

Article Improving Upstream Predictability
“We’ve consistently been seeing titers in the range of 4–6 g/L in [monoclonal antibody] mAb fed-batch processing within a chemically defined media environment. This environment, in turn, results in mo…

Article Re-use of Protein A Resin: Fouling and Economics
Mar 01, 2015 By Anurag S. Rathore, Mili Pathak, Guijun Ma, Daniel G. Bracewell BioPharm International Volume 3, Issue 28 In the past two decades, Protein A affinity chromatography ha…

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