Search results for " PAT"
Article
Moving PAT from Concept to Reality
With sufficient advances, emerging PAT solutions should ultimately make real-time release testing possible.
In-line, at-line, and on-line
To understand the state of PAT technology development,…
Article
Improving PAT for Biologics
Implementing PAT for bioprocesses presents unique challenges given the greater complexity of cell-culture and fermentation processes, the variability of raw materials (particularly living organisms), …
Article
QbD and PAT in Upstream and Downstream Processing
Some of these CQAs, such as glycoxylation pattern for monoclonal antibody (mAb) products, are primarily impacted by the upstream process and are particularly important to monitor during process develo…
Article
The Importance of Process Intensification and PAT for Achieving Real-Time Release
While many analytical technologies may be classified as PAT, the goal of many manufacturers is to minimize the number of technologies that human operators must manipulate by automating sample collecti…
Article
Leveraging Data for Better Biopharmaceutical Process Control
Biopharmaceutical companies are starting to use PAT in more advanced development and even some manufacturing work, while methods are also moving downstream. Francisca F. Gouveia, a biopharmaceutical p…
Article
The Lifecycle Change of Process Validation and Analytical Testing
Therefore, finding a balance between relying on semi-automated statistical tools and human monitoring is potentially one of the key elements to success
APPLYING PAT
BioPharm: How ma…
Article
Remote Monitoring and Big Data Advance Upstream Automation
Automating these activities would not only help reduce laboratory resource constraints and improve data integrity, but enable the incorporation of more advanced feed strategies involving PAT and produ…
Article
Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
…Cell perfusion
7:16 - Critical process parameters and CQA
9:25 - PAT
10:35 - Continuous manufacturing
Transcript
BioPharm Internati…
Article
Digitalization: The Route to Biopharma 4.0
In a case study, it was seen that integrating a distributed control system with the sensors and control elements provided a means to implement QbD and PAT in continuous manufacturing (12). In addition…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
In addition, across the industry, Sanderson notes that vendors are investigating the use of novel PAT tools and sensors such as Raman spectroscopy and carbonate and glucose sensors to enhance process …