Search results for " PAT"

Article Moving PAT from Concept to Reality
With sufficient advances, emerging PAT solutions should ultimately make real-time release testing possible. In-line, at-line, and on-line To understand the state of PAT technology development,…

Article Improving PAT for Biologics
Implementing PAT for bioprocesses presents unique challenges given the greater complexity of cell-culture and fermentation processes, the variability of raw materials (particularly living organisms), …

Article QbD and PAT in Upstream and Downstream Processing
Some of these CQAs, such as glycoxylation pattern for monoclonal antibody (mAb) products, are primarily impacted by the upstream process and are particularly important to monitor during process develo…

Article The Importance of Process Intensification and PAT for Achieving Real-Time Release
While many analytical technologies may be classified as PAT, the goal of many manufacturers is to minimize the number of technologies that human operators must manipulate by automating sample collecti…

Article Leveraging Data for Better Biopharmaceutical Process Control
Biopharmaceutical companies are starting to use PAT in more advanced development and even some manufacturing work, while methods are also moving downstream. Francisca F. Gouveia, a biopharmaceutical p…

Article The Lifecycle Change of Process Validation and Analytical Testing
Therefore, finding a balance between relying on semi-automated statistical tools and human monitoring is potentially one of the key elements to success APPLYING PAT   BioPharm: How ma…

Article Remote Monitoring and Big Data Advance Upstream Automation
Automating these activities would not only help reduce laboratory resource constraints and improve data integrity, but enable the incorporation of more advanced feed strategies involving PAT and produ…

Article Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
…Cell perfusion  7:16 - Critical process parameters and CQA 9:25 - PAT  10:35 - Continuous manufacturing  Transcript BioPharm Internati…

Article Single-Use Technologies Prove Effective for Viral Vector Process Development
In addition, across the industry, Sanderson notes that vendors are investigating the use of novel PAT tools and sensors such as Raman spectroscopy and carbonate and glucose sensors to enhance process …

Article QbD Improves Cell-Culture Process Control
In addition, this use of PAT would allow for on-line prediction of the critical quality attributes (CQAs) required to maintain product quality and offer the ability for real-time product quality contr…

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