Search results for " ion exchange"

Article Updated Ion Exchange Chromatography (IEX) Handbook
In addition to a new chapter on large-scale purification, the handbook describes each product and how to use them, and provides useful hints and tips for getting great results from your ion exchange c…

Article Online Ion Exchange Chromatography (IEX) Resource Hub—All in One Place
If you use ion exchange chromatography, check out GE Healthcare's online IEX resource hub for useful information, from fundamentals to tips for advanced practitioners. Read more

Tip How to screen for binding conditions with high-capacity ion exchangers
Some proteins exhibit unexpected behavior on ion exchangers that have been engineered for extra high binding capacity. For example, dynamic binding capacity for a specific molecule might increase wh…

Poster Polishing of monoclonal antibodies using a polymer grafted cation exchanger
A typical monoclonal antibody (MAb) purification process begins with capture on a protein A chromatography medium (resin), followed by polishing steps by for example ion exchange chromatography. The …

Resource Tips for successful ion exchange chromatography
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Article Bioterminology: A Guide to the Biopharmaceutical Lexicon
Bioterminology: A Guide to the Biopharmaceutical Lexicon This lexicon was generated by the editors of BioPharm International magazine. Please feel free to email your suggestions for terms that s…

Article Purification Strategies to Process 5 g/L Titers of Monoclonal Antibodies
This requires the modification of a platform purification process comprising Protein A chromatography as the robust capture step followed by two ion exchange chromatography steps. Because buffer and p…

Article Evolution of the Monoclonal Antibody Purification Platform
Though extremely efficient and effective, the step primarily suffers from the significantly high cost of Protein A resins in comparison to other popular modes of chromatography (such as ion exchange).…

Article Mixed-Mode Chromatography in Downstream Process Development
In these cases, single-mode chromatography materials like ion exchange or hydrophobic resins often fail, in particular if the feedstock contains large amounts of complex colored impurities like melano…

Article Process Chromatography: Continuous Optimization
“Different ion exchange chemistries can offer unique selectivity depending on the purification needs, so a variety of chemistries are tested based on the application,” Parra says. Affinity resins …

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