Search results for " plates"
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How to Use Multiwell Plates With Manual Operation
High-throughput tools like PreDictor™ plates prefilled with chromatography resins make it possible to explore a large characterized space for optimizing process conditions. They save time and require …
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Tutorial: Automated Preparation of Buffer Plates
This video shows how to use the BufferPro function in ÄKTA avant for automated preparation of buffer plates.
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Development of Purification for Challenging Fc-Fusion Proteins
In this study, utilizing a combination of high-throughput condition screening in 96-well plates, optimization in small-scale column models, and a novel virus-spiking strategy, the authors have develop…
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Tools for Continuous Bioprocessing Development
For instance, in cell culture, the typical biopharmaceutical company uses at least a dozen different platforms, including shallow-well microtiter plates; deep-well microtiter plates; shake flasks; ben…
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Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
An example illustrating the use of HTPD and DoE to optimize the first polishing step for a mAb of interest is discussed herein, and the roles of both HTPD 96-well filter plates and mini-columns are hi…
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Report from the 6th International HTPD Conference
HTPD was mainly limited to 96-well plates filled with chromatography resins used for resin selection and initial screening of running conditions. Since then, HTPD in chromatography applications has be…
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High-Throughput Process Development Handbook
Evaluating chromatographic conditions can be performed in parallel using 96-well filter plates. As a result, a large number of experimental conditions can be evaluated simultaneously. This allows a la…
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Digitalization: The Route to Biopharma 4.0
In microbial cell cultures, scale down models such as micro well plates (3) and deep well plates are employed, whereas shake tubes/flasks are widely used in mammalian cultures (4). However, most of th…
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Miniaturization to Become Even More Successful
Several talks focused on the use of miniaturized columns and screening plates, such as PreDictor 96-well plates and PreDictor RoboColumn™ units, and the possibility of these formats to become even mor…
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High-Throughput Process Development in an Historical Environment
In the presented work, instead an automated platform using 96-well plates for parallel screening of inclusion body solubilization and protein refolding conditions was shown. With this approach, 24 sol…