Search results for "EX" in Posters
Poster
Fast Trak Services: a collaborative project to accelerate downstream biosimilar process development
The molecule exhibits monoclonal antibody (mAb) behavior, however, with a challenging glycosylation profile and complex tertiary and quaternary structures. Consequently, low product recovery and pur…
Poster
Residual DNA analysis in influenza vaccine processing
In batch mode, recoveries of > 80% were achieved, but the technique exhibited matrix effects on real process samples. In capture mode, recoveries of 40%–60% were achieved after elution. However, recov…
Poster
A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
This poster presents a newly designed, high-capacity Protein A resin, MabSelect™ PrismA, which offers alkali stability on par with ion exchange and hydrophobic interaction chromatography resins, enabl…
Poster
Rapid Process Development of a CIEX Step for a Biosimilar
A cation exchange (CIEX) chromatographic step was developed as part of a collaborative project, where expertise in the field of downstream purification and bioprocessing was combined with specific bio…
Poster
Opportunities, Challenges, and Economic Drivers for Start-to-Finish Continuous Biomanufacturing
Many large biopharmaceutical organizations are exploring potential solutions to drive continuous operations on the manufacturing floor.
Continuous biomanufacturing carries the hope for achieving …
Poster
Adenovirus production in a single-use stirring tank bioreactor system
Human adenovirus 5 expressing green fluorescent protein (GFP) was used as a model system. By evaluating different cell culture media (CCM) and optimizing the virus propagation in small scale, the proc…
Poster
Scalable Continuous Chromatography Process for Enhanced Efficiency in Biomanufacturing
One such option explored is continuous, or connected, biomanufacturing. For continuous chromatography, interest in techniques such as periodic counter current chromatography (PCC) is increasing.
…
Poster
Strategies for optimized cell culture media: Effectively using design space to influence product quality
Results indicate that several conditions improved titer and maximized main variant expression. A subsequent round focused on finding optimal levels for key drivers of higher titer and main variant exp…
Poster
Scale-up and process economy calculations of a dAb purification process using ready-to-use products
The results show that although operating expenses can be more extensive when scale and number of batches increase, ready-to-use equipment and ready-made buffers offer great time-savings. As less time …
Poster
Unlocking the potential for efficiency in downstream bioprocesses
Additionally, flexibility needs to be increased and time to market reduced. Upstream processes are more efficient and product higher titers than before. With these improvements, new challenges arise. …