Search results for " scaling"

Article New Therapies Present Scaling Challenges
In mAb production, increasing production volume to commercial scale is typically a scaling operation. Bioreactor size can be increased (scale up), or the number of bioreactors used can be increased (s…

Article Scaling Up Novel Therapies
Use of digital modeling is helping developers understand processes at small scale and assess operations before scaling up, he says.  Bioreactors also present opportunities for scaling out.…

Article Going Small to Achieve Success on the Commercial Scale
Scale-down modeling is instrumental in supporting the development of downstream biopharma manufacturing processes. By Cynthia A. Challener Biopharmaceutical manufacturing involves a series o…

Poster Scaling In-Line Buffer Preparation from Process Development to Manufacturing
Preparing buffers for large-scale chromatography requires significant resources: time, money, and storage space. Inline conditioning (IC) is one possible way to address these challenges. At the same t…

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Article Reference Guide: Empty Chromatography Columns for Lab Scale
This guide offers an overview of GE Healthcare Life Sciences’ empty chromatography columns designed for use in lab scale, including: • Main technical specifications • Compatibility with base matri…

Article Single-Use Chromatography: Adapting to Manufacturing Scale
Single-use technologies offer the flexibility needed to meet the demands of multiproduct facilities. The capital investment is lower, and substantial time savings can be made when eliminating cleani…

Article Taking Prepacked Columns to Manufacturing Scale
Prepacked chromatography columns in biomanufacturing can save time, but also present concerns related to delivery lead times, capacity, and operational cost. Learn more here about ways to address…

Article Scaling an mAb Production Process to Xcellerex Bioreactors
This article discusses moving a monoclonal antibody (mAb) production process from a microscale bioreactor to the Xcellerex XDR single-use platform. Learn more >>

Poster Experimental investigation of scale effects in high throughput process development studies
High throughput process development (HTPD) has already been proven successful, mainly because it allows for faster investigation of larger experimental space of process conditions, with smaller sample…

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