Search results for " scaling" in Articles / App Notes
Article
New Therapies Present Scaling Challenges
In mAb production, increasing production volume to commercial scale is typically a scaling operation. Bioreactor size can be increased (scale up), or the number of bioreactors used can be increased (s…
Article
Scaling Up Novel Therapies
Use of digital modeling is helping developers understand processes at small scale and assess operations before scaling up, he says.
Bioreactors also present opportunities for scaling out…
Article
Current Techniques and Challenges Presented in Scaling Between Bioreactors
Jeanne Linke Northrop: Are there special skills required by that person to define that scaling strategy?
Andreas Castan: Yes, there are two important skill sets required. Knowing the process…
Article
Going Small to Achieve Success on the Commercial Scale
Scale-down modeling is instrumental in supporting the development of downstream biopharma manufacturing processes.
By Cynthia A. Challener
Biopharmaceutical manufacturing involves a series o…
Article
Simplify-bioreactor scale up and scale down: applications and tools
A well-designed scaling strategy, workflows, and easy-to-use tools will facilitate the scaling exercise. In this article we present the theory for bioreactor scaling and propose a workflow to scale th…
Article
Scaling Up an E. coli Upstream Process for Plasmid DNA Production — from 2.5 to 160 L scale Fermenters
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This article summarizes the results of Escherichia coli growth performance for plasmid production in a 5 L glass fermentor, which was scaled up to 80 and 160 L scale in Xcellerex™ X…
Article
Improving Productivity During Process Development and Scaling of Your Process
…lture to larger processes and challenges to consider
5:17 - Strategies and tools to consider for scaling to bioreactors
6:57 - Important recommendations for developing new processes
Article
Interactive eBook - Understand and unlock the potential of digital scaling
Ready for smarter scaling? Explore the possibilities with a digital process to reduce time and costs associated with your operations. Get started by downloading our free eBook.
DOWNLOAD EBO…
Article
Challenges of scaling up buffer production for GMP and how to evaluate different solutions
This virtual workshop presents different options for scaling up buffer production. You will learn at what scale does it make sense to outsource your buffer production or invest in a hardw…
Article
Approaches to scaling up Chromatography Processes
Scaling up chromatography resins requires a thorough understanding of their intended use.
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