Search results for " AAV"

Article Gene Therapies Push Viral Vector Production
Of these, AAVs have gained much attention as a gene delivery vehicle and are being explored for their commerical viability. The commercial viability of other virus types also continues to be explored,…

Article A Look at the Affinity Chromatography Landscape
Baker points to ligands for AAV vector purification with both broad and specific serotype selectivities. “These developments have made the purification of certain vectors much more efficient and consi…

Article Scaling Up Novel Therapies
For example, a new collaboration (1) that involves GE Healthcare, Cobra Biologics, and UK’s Center for Process Innovation, is working on new ways to use fiber-based chromatography to improve AAV scale…

Article Flexible Facilities for Viral Vector Manufacturing
Whereas for in-vivo gene therapies, using mostly AAV, the scale varies depending on the patient population, disease type, and route of injection, from a few 10 L up to 2000 L. For example, for Duchene…

Article Ensuring Viral Safety of Viral Vaccines and Vectors
Chromatography has been shown to remove PCV (33), and ion exchange and affinity chromatography have been shown to purify vectors such as AAVs. However, because achieving robust clearance is challengin…

Article The Challenge of Disruptive Technologies in Bioprocessing
Thermo Fisher Scientific has commercialized three POROS CaptureSelect AAV affinity resins to establish industrialized platforms for the purification of adeno-associated virus (AAV). The move is meant …

Article Production of Recombinant Adeno-associated Virus Vectors Using Microcarrier Culture of HEK293T Cells
As of March 2020, more than 4310 gene therapy clinical trials have been performed worldwide, with only 518 of them in Phase III and Phase IV. As the gene therapy projects enter clinical Phase III or g…

Article FDA Seeks to Enhance Manufacturing of Cell and Gene Therapies
FDA Seeks to Enhance Manufacturing of Cell and Gene Therapies More consistent and reliable production processes are critical for advancing innovative treatments. By Jill Wechsler …