Search results for " media"

Article A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
By Satish Mallya, Benjamin Lay, Lihong McAleer, Alexandria Emory, Nataliya Afonina Abstract Cell-culture media are essential raw materials that are required for the manufacture of biotherapeut…

Article Impact of Media Components on CQAs of Monoclonal Antibodies
The cell-culture process and media are known to have a significant effect on the expression and stability of therapeutic products as well as their critical quality attributes (CQAs) including glycosyl…

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Article Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
The resulting push to eliminate animal-sourced materials drove the innovation of cell-culture media technology, which ultimately gave rise to the impressive chemically-defined, animal-component-free p…

Poster Strategies for optimized cell culture media: Effectively using design space to influence product quality
Balancing the many individual media components required to achieve high titers and support critical protein quality attributes can be challenging. Here we highlight a statistical design strategy to op…

Tip Resuspending chromatography media in a column or other vessel
Do not risk damaging the resin or the column by using steel or sharp plastic devices that have to be dug in to the media and forcibly stirred. Three different diameters of this simple and effective de…

Poster Repurposing Fed-Batch Media and Feeds for Highly Productive CHO Cell Perfusion Processes
Here, they show that they can obtain culture media that successfully support perfusion cultures in bioreactors at cell-specific perfusion rates (CSPR) below 25 pL/cell/day. High productivities and fav…

Tip Alternative media storage solution
In tests covering a range of media with 5 different microbial organisms we have found 2% benzyl alcohol to offer at least the same antimicrobial effectiveness as 20% ethanol. For details see the…

Tip How to clean chromatography media and equipment
For further information, see the following application note: Use of sodium hydroxide for cleaning and sanitizing chromatography media and systems, GE Healthcare, 18-1124-57, Edition AG (2009). (Click …

Article Security of supply program for chromatography media
As chromatography media usually are singlesourced, its supply security is of key concern for the pharmaceutical industry.  In view of global financial uncertainties and recent natural disasters, such …

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