Search results for " scale down model"

Article Modeling Bioreactor Performance
Model effectiveness is determined by the quality and composition of the data inputs. By Cynthia A. Challener Bioreactor design, including the geometry of the tank and impeller and the locati…

Article Cell-Culture Advances Test Bioreactor Performance Models
The evolution of cell-culture technology is driving the need for improvements in modeling solutions. By Cynthia A. Challener  Modeling and simulation are recognized to provide assistance i…

Article Modeling the Degradation of mAb Therapeutics
Modeling the Degradation of mAb Therapeutics Kinetic models can be used to study aggregation and fragmentation to help ensure stability. By Anurag S. Rathore, Rohit Bansal …

Article The Need for Advanced Process Modeling for New Therapeutic Biologics
The Need for Advanced Process Modeling for New Therapeutic BiologicsThe trend toward personalized medicines includes more complex manufacturing cycles that can benefit from advanced process modeling e…

Article Using Digital Twins to Model Process Chromatography
Mechanistic models provide process understanding for developing robust manufacturing processes and for scale up and tech transfer. By Jennifer Markarian A digital twin is a model of a proces…

Article Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
I am thinking, for example, of explaining significant changes in the chromatograms of scale down models, or of converting batch processes to continuous multi-column processes entirely in silico. In ma…

Article Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Modeling and miniaturization were two key take-home messages from the 4th High Throughput Process Development (HTPD) conference organized in October 2017 in Toledo, Spain. The conference brought tog…

Article A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAb at Large Scale
Read more>> As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quickly follow…

Article A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
Read full article>> As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quic…

Resource Mechanistic Modeling: Theory to Implementation
Is your downstream process development workflow relying on experimental data alone, or are you leveraging mechanistic modeling? Gain a better understanding of effective modeling implementation to deve…

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