Search results for " Mabs"

Article Modeling the Degradation of mAb Therapeutics
It can, either directly or indirectly, affect mAbs’ biological activity as well as toxicity (4).  The instabilities associated with mAbs can be broadly classified as either physical or chemical…

Article Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
An advantage in the area of mAbs is the possibility of using a purification platform approach. The typical platform process is generally comprised of an initial capture step with Protein A-chromatogra…

Article mAbs to Watch in 2016
Although the pharmaceutical manufacturers developing these mAbs will likely seek various indications for their products, the preliminary indications include treatments for various cancers, multiple sc…

Article Developing a mAb aggregate removal step by high throughput process development
Traditionally, MAbs are purified in a three-step process. First, the target is captured by chromatography with Protein A media, and two subsequent polishing steps are then performed according to a var…

Article Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Enormous success achieved with mAbs can be attributed to their distinctive beneficial properties and advantages, which include high binding specificity and affinity, availability of humanized forms th…

Article Faster scale-up of a two-step MAb process with AxiChrom™ columns and ReadyToProcess™ solutions
The addition of readyto-use solutions to the upstream/downstream process significantly shortens the time-to-clinic journey for MAbs. Scaling up with AxiChrom columns In the scale-up describe…

Article Rapid process development for the purification of a MAb using ÄKTA™ avant 25
Abstract ÄKTA avant 25 system controlled by UNICORN™ 6 software was used to develop a two-step chromatography process for purification of a monoclonal antibody (MAb). MabSelect SuRe™, a pro…

Tip A Polished Performance in MAb Purification
However, MAbs may leak from the column during washes and/or early in the gradient. If MAb is eluting during the wash step, you could use buffer with lower conductivity and/or avoid buffer blending’s i…

Poster Modes of controlling charge variant distribution in Mab production
Charge variant distribution is a critical quality attribute for MAbs and is therefore of interest to monitor and control during the production process. In this study, we investigated the effects of ce…

Poster Multimodal chromatography media to resolve purification platform challenges of ‘tricky’ MAbs
Monoclonal antibodies (Mabs) are commonly purified using platform approaches, where the initial protein A capture step is followed by two polishing steps. Protein A capture is a generic step that do…

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