Search results for " Mabs"
Modeling the Degradation of mAb Therapeutics
It can, either directly or indirectly, affect mAbs’ biological activity as well as toxicity (4). The instabilities associated with mAbs can be broadly classified as either physical or chemical…
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
An advantage in the area of mAbs is the possibility of using a purification platform approach. The typical platform process is generally comprised of an initial capture step with Protein A-chromatogra…
mAbs to Watch in 2016
Although the pharmaceutical manufacturers developing these mAbs will likely seek various indications for their products, the preliminary indications include treatments for various cancers, multiple sc…
Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Enormous success achieved with mAbs can be attributed to their distinctive beneficial properties and advantages, which include high binding specificity and affinity, availability of humanized forms th…
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
Innovative approaches, including ready-to-use materials and in-line dilution, can significantly streamline overall bioprocessing operations. By: Pranav Vengsarkar and Nandu Deorkar I…
Modes of controlling charge variant distribution in Mab production
Charge variant distribution is a critical quality attribute for MAbs and is therefore of interest to monitor and control during the production process. In this study, we investigated the effects of ce…
Integrated Semi-Continuous Process for mAb Production
A complete process for the production of a biopharmaceutical consists of a great number of distinct unit operations, for example, cell culture, filtration, and chromatography. Linking these differen…
Developing a Closed, Connected Single-Use mAb Purification Process
In the Protein A step, Fibro PrismA is compared with MabSelect PrismA regarding process time, recovery, and purification performance.
Speeding Up mAb Purification Using Fiber-based Technology
Learn how to automate high throughput monoclonal antibody (mAb) purification and improve throughput significantly using fiber-based chromatography. With purification cycles in minutes rather th…
Factors Which Impact mAb Process Scale-Up
Thinking about your mAb scale-up processes early on can help avoid common pitfalls. Fast Trak™ scientists discuss factors that can influence a successful scale-up outcome.