Search results for " titer"

Article Purification Strategies to Process 5 g/L Titers of Monoclonal Antibodies
Blank ABSTRACT Monoclonal antibody purification processes have been challenged recently to recover 5 g/L cell culture titers in existing manufacturing facilities. This requires the modificatio…

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Poster Efficient, higher titer monclonal antibody production in a fed-batch process using single use stirred-tank and rocking bioreactor systems
This application note shows the feasibility of monoclonal antibody (MAb) production in fed-batch processes using the single-use Xcellerex™ XDR-200 stirred-tank and ReadyToProcess WAVE™ 25 rocking…

Article Economic drivers and trade-offs in antibody purification processes
Farid, PhD  ABSTRACT Increasing titers in mammalian cell culture has recently shifted the focus of process development efforts toward improving the economics of product recovery and purification …

Article Comparing Protein A Resins for Monoclonal Antibody Purification
With greater economic pressure on monoclonal antibody (mAb) production for therapeutic and research uses, antibody titers in mammalian cell culture have increased dramatically over the past 20 years. …

Article Generating a Fully Processed Antibody
…rotein needs to be produced at high enough levels to fully process all the biopharmaceutical at high titers without interfering with normal cell growth and the secretion of the molecule. Finally, som…

Article The Development and Application of a Monoclonal Antibody Purification Platform
…division, including how the individual unit operations have been affected by increasing cell culture titers and subsequent changes in the impurity profile, as well as viral clearance issues. The plat…

Article Gene Therapies Push Viral Vector Production
This makes it relatively straightforward to achieve desired titers and to achieve a single integration element, Carstens emphasizes. Downsides include the fact that it is more difficult to achieve lar…

Article Concentrating Feed—an Applicable Approach to Improve Antibody Production
Cell counts, antibody titer, protein quality analysis, and qPCR array. Cell-culture samples were counted by a Vi-CELL (Beckman-Coulter) using the trypan blue exclusion method. The pH and metabolites i…

Article Trends in Fermentation and Cell Culture Equipment
Galliher acknowledges that while it’s a hotly debated topic, there is a trend to drive the higher titers from those working with cell cultures—but in point of fact, those working downstream are strugg…

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