Search results for "scale up"

Article New Therapies Present Scaling Challenges
Bioreactor size can be increased (scale up), or the number of bioreactors used can be increased (scale out). In addition, mammalian cell culture technology has advanced such that producing multi-kilog…

Article Scaling Up Novel Therapies
Bioreactor scale-up In more traditional biopharmaceutical development, bioreactors are typically the most difficult pieces of equipment to scale up, says Fredrik Lundström, product manager for…

Article Going Small to Achieve Success on the Commercial Scale
Scale-down modeling is instrumental in supporting the development of downstream biopharma manufacturing processes. By Cynthia A. Challener Biopharmaceutical manufacturing involves a series o…

Article How to Optimize and Scale Up AAV Production
In this article from a roundtable discussion, four experts from academia and industry met to discuss challenges in refining and scaling up AAV production pipelines to meet the increasing demand for …

Article A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
Read full article>> As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quic…

Article A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAb at Large Scale
Click here to read more >> As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quick…

Poster Scaling In-Line Buffer Preparation from Process Development to Manufacturing
Preparing buffers for large-scale chromatography requires significant resources: time, money, and storage space. Inline conditioning (IC) is one possible way to address these challenges. At the same t…

Article Reference Guide: Empty Chromatography Columns for Lab Scale
This guide offers an overview of Cytiva's empty chromatography columns designed for use in lab scale, including: • Main technical specifications • Compatibility with base matrix Download …

Article Single-Use Chromatography: Adapting to Manufacturing Scale
Single-use technologies offer the flexibility needed to meet the demands of multiproduct facilities. The capital investment is lower, and substantial time savings can be made when eliminating cleani…

Article Taking Prepacked Columns to Manufacturing Scale
Prepacked chromatography columns in biomanufacturing can save time, but also present concerns related to delivery lead times, capacity, and operational cost. Learn more here about ways to address…

Next Page