Search results for " upstream"
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Balancing innovation, speed, and robustness to improve efficiency in upstream process development.
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Using Modeling to Improve Data Analytics for Upstream Bioprocessing Workflows
Recent trends in data analytics highlight the use of modeling techniques to improve process control and monitoring in biopharmaceutical production.
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Unifying Continuous Biomanufacturing Operations
The most efficient upstream processing systems in biologics manufacturing seek to mimic the body’s treatment of cells, so a constant level of incoming nutrients and outgoing waste products is necessar…
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Continuous Processing for the Production of Biopharmaceuticals
The industry already has experience in terms of continuous upstream processing. Perfusion technology has been successfully used for the production of biotherapeutics for more than a decade. In the pas…
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Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Continuous processing upstream has been around for decades as perfusion (e.g., fiber-based perfusion bioreactors for fused-cell hybridoma culture in the 1980s). But that’s essentially the only continu…
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The New World of Biopharmaceutical Manufacturing
Single-use technology has also precipitated changes in upstream and downstream processing.
Pharmaceutical Technology spoke with Eric Langer, managing partner at BioPlan Associates; John …
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Hybrid Bioprocessing: A Q&A with Andrew Sinclair
What could be the main reasons and/or the main drivers that hybrid bioprocessing are being used? Is there a difference between upstream and downstream?
If we look at the key benefits that are attr…
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Continuous Manufacturing: A Changing Processing Paradigm
In addition, there is some trepidation surrounding the integration of upstream and downstream processes and the interaction between unit operations, as it is well documented that changes upstream affe…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
The presence of serum, culture harvest viability, turbidity, cell lysis reagents, contaminant DNA levels, and residual transfection agents are all upstream factors. Overall process scalability and rob…