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Search results for "cell therapy"

Article Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
The necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process. By Marcos Simon, Juan J. Giner-Casares Cell…

Article The Evolving Role of Starting Materials in Cell and Gene Therapy
  Cell therapy starting material—where does it feed into critical process points? Donor recruitment: Necessary at each stage of clinical testing. Must have a strong donor netw…

Article Mapping a Route for Cell and Gene Therapy Process Development
cell therapy applications), the focus of scaling of the manufacturing process may be different. Scale up and mass production of the final product starting from a small seed bank (for instance, …

Article Design Considerations for a Commercial Cell and Gene Therapy Facility
The workflows of a cell therapy or a gene therapy differ from each other and from those of therapeutic antibodies, so the design and layout of the manufacturing facility must take these workflows into…

Article Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
However, adenovirus and retrovirus are also of interest in this space (the latter being primarily used in Chimeric antigen receptor T (CAR-T) cell therapy and not as a primary vehicle). and must be pr…

Article Changing the Culture of Cell Culture: Applying Best Practices and Authentication to Ensure Scientific Reproducibility
By Leonard P. Freedman, Mark C. Gibson, Richard M. Neve Irreproducible preclinical research is a global, expensive, and well-recognized problem that contributes to delays and increased costs of …

Article Best Practices for Selecting a Top-Quality Cell Line
Irina Shi - Stock.Adobe.com Leveraging automation and a step-by-step approach are keys to success. By Cynthia A. Challener Cell lines determine the performanc…

Article Taking a “Development-by-Design” Approach to Cell Therapies
More CDMOs are entering cell therapy market niche Demand for specialized cell therapy manufacturing and development services is also growing, and has attracted Lonza Bioservices, Cognate BioServic…

Article FDA Seeks to Enhance Manufacturing of Cell and Gene Therapies
While there is great excitement over the potential of CAR-T (chimeric antigen receptor) cell therapy to target and activate T cells to eliminate a cancerous or other undesirable cell type, Marks cauti…

Article Cytiva and 4Tune Engineering Collaborate on Cell Therapy Quality Risk Management
…t they have entered into an agreement to include 4Tune Engineering’s iRISK platform in Cytiva’s cell therapy product offering. Cytiva customers in the early stages of cell therapy product developm…