Search results for " cell culture media"

Article A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
The authors describe the ways in which manufacturers can mitigate the risks related to the integrity of recombinant transgenes expressed in CHO cells. By Luhong He, Christopher Frye Abstract …

Article Scale-up of adherent Vero cells grown on Cytodex microcarrierrs using ReadyToProcess equipment
In cell culture-based vaccine production, scale-up of adherent cells is challenging. This study shows a process for scaling up adherent Vero cells from static cell factories to influenza producti…

Article The Evolving Role of Starting Materials in Cell and Gene Therapy
The Evolving Role of Starting Materials in Cell and Gene Therapy Accelerated approval pathways and growing demand for cell and gene therapies are putting pressure on providers of cellular starting m…

Article Best Practices for Selecting a Top-Quality Cell Line
Irina Shi - Stock.Adobe.com Leveraging automation and a step-by-step approach are keys to success. By Cynthia A. Challener Cell lines determine the performanc…

Article Mapping a Route for Cell and Gene Therapy Process Development
While cell and gene therapies differ in many ways, some of the best practices for process development and validation are similar. By Cynthia A. Challener …

Article Design Considerations for a Commercial Cell and Gene Therapy Facility
The commercialization of cell and gene therapies has become a reality, prompting deeper considerations of logistics, technology, and design for manufacturing facilities. By Feliza Mirasol …

Article Large-scale cell culture using Cellbag™ bioreactors with embedded optical sensors
This application note describes how WAVE Bioreactor™200 system has been used with a disposable Cellbag 200L with embedded DOOPT II and pHOPT sensors to cultivate cells.  For a download of the complete…

Article Implications of Cell Culture Conditions on Protein Glycosylation
The authors present a review of the techniques commonly used for glycosylation analysis. By Michiel E. Ultee, PhD, Dr. Richard Easton This article reviews the implications of cell-culture co…

Poster Strategies for optimized cell culture media: Effectively using design space to influence product quality
Here we highlight a statistical design strategy to optimize cell culture media to influence the charge variant profile of a mAb produced in CHO DG44 cells. Media optimization requires incorporatio…

Article Troubleshooting Cell Culture Media for Bioprocessing
Advances in cellular and metabolic understanding, coupled with high-throughput applications, have evolved approaches in media development and optimization, resulting in innovative cell culture media w…

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