Search results for " scale-down"
Poster
Reduce Risk of Failure in Your Virus Clearance Study by Choosing Robust Scale-Down Chromatography Tools
Viral clearance studies are usually performed using a scale-down model mimicking the large-scale process step. For chromatography steps, using a scale-down model limits the amount of sample and resin …
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New HiScale™ 10/40 for Scale-Down Studies
HiScale 10/40 column is especially suitable for scale-down studies used in, for example, viral clearance evaluation in downstream processing. The small inner diameter (10 mm) and flexible adapters min…
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New Column for Scale-Down Studies
Their dimensions—narrow 10 mm inner diameter, combined with 20 cm bed height typically used in biomanufacturing—make these columns suitable for scale-down studies such as viral clearance studies.
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FAQ: Scale-up and scale-down with mechanistic modeling
The model eases scale-up and scale-down between lab scale and production scale. To apply model-based scale-up and scale-down in a straightforward manner, you must know the scale-dependency of the unde…
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Going Small to Achieve Success on the Commercial Scale
Conducting the required number of studies on the commercial scale is not practical; scale-down models are therefore employed to determine optimum conditions for downstream separation processes, includ…
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Tools for Continuous Bioprocessing Development
Reliable and standardized scale-down models would allow large-scale manufacturing and product development to be decoupled. If the large-scale bioreactor is well characterized, a small-scale system can…
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Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
One approach to scale-down freeze-thaw process characterization studies is to use a temperature-controlled chamber to expose small samples of a formulation to time-temperature profiles that simulate a…
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Putting Viral Clearance Capabilities to the Test
Viral clearance studies assess the capability of a downstream process to remove or inactivate potential contaminants and are based on a scale-down model of a biopharmaceutical production process. The …
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Scaling Up Novel Therapies
Scale-up and scale-down are codependent, says Chatel. “The synergies between the two are essential and must be embraced by equipment manufacturers,” he says. The obvious target for scale-down models t…
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Being Thorough When Transferring Technology
…cs): The major challenges in technology transfer for any modality exist when there are known gaps in scale-down models or if the scalability from the small-scale to large-scale is unknown; for exampl…