Search results for " scale-down"

Poster Reduce Risk of Failure in Your Virus Clearance Study by Choosing Robust Scale-Down Chromatography Tools
Viral clearance studies are usually performed using a scale-down model mimicking the large-scale process step. For chromatography steps, using a scale-down model limits the amount of sample and resin …

Article New HiScale™ 10/40 for Scale-Down Studies
HiScale 10/40 column is especially suitable for scale-down studies used in, for example, viral clearance evaluation in downstream processing. The small inner diameter (10 mm) and flexible adapters min…

Article New Column for Scale-Down Studies
Their dimensions—narrow 10 mm inner diameter, combined with 20 cm bed height typically used in biomanufacturing—make these columns suitable for scale-down studies such as viral clearance studies. …

Article Going Small to Achieve Success on the Commercial Scale
Conducting the required number of studies on the commercial scale is not practical; scale-down models are therefore employed to determine optimum conditions for downstream separation processes, includ…

Article Tools for Continuous Bioprocessing Development
Reliable and standardized scale-down models would allow large-scale manufacturing and product development to be decoupled. If the large-scale bioreactor is well characterized, a small-scale system can…

Article Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
One approach to scale-down freeze-thaw process characterization studies is to use a temperature-controlled chamber to expose small samples of a formulation to time-temperature profiles that simulate a…

Article Putting Viral Clearance Capabilities to the Test
Viral clearance studies assess the capability of a downstream process to remove or inactivate potential contaminants and are based on a scale-down model of a biopharmaceutical production process. The …

Article Scaling Up Novel Therapies
Scale-up and scale-down are codependent, says Chatel. “The synergies between the two are essential and must be embraced by equipment manufacturers,” he says. The obvious target for scale-down models t…

Article Being Thorough When Transferring Technology
…cs): The major challenges in technology transfer for any modality exist when there are known gaps in scale-down models or if the scalability from the small-scale to large-scale is unknown; for exampl…

Article Downstream Processing for Cell-Based Therapies
Addressing the DSP challenges Table I: Overview of ultra scale-down tools reported in literature as predictive tools for several different large-scale downstream processing steps and/or processing…

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