Search results for " scale-down"
Article
Maximum Output Starts with Optimized Upstream Processing
Furthermore, Chilima observes that by using scalable technologies that have representative scale-down models early in the process development, companies are able to evaluate the capacity needed early …
Article
Downstream Processing for Cell-Based Therapies
Addressing the DSP challenges
Table I: Overview of ultra scale-down tools reported in literature as predictive tools for several different large-scale downstream processing steps and/or processing…
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Modeling Bioreactor Performance
Modeling is used to gain insight into not only bioreactor performance, but to evaluate the economics and operational excellence of bioprocesses, as well as for process optimization (scale-up, scale-do…
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Platform Approach Speeds Process Development
Scale-up, scale-down, and process transfer
The transfer of biopharmaceutical production processes to clinical and commercial scales is challenging. The developmental work leading to an optimized p…
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Digitalization: The Route to Biopharma 4.0
Semi-Continuous Scale-Down Models for Clone and Operating Parameter Screening in Perfusion Bioreactors. Biotechnol Prog. 2019, 35 (3), e2790. DOI: 10.1002/btpr.2790.
5. Wolf, M.; Bielser, J. M.;…
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A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAb at Large Scale
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As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quickly follow…
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A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
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As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quic…
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Case Study: Virus Reduction of an Affinity Capture Step
In this study, the virus reduction of an affinity capture step was evaluated in a scale-down column format. The study was performed by a third-party viral testing laboratory in collaboration with a bi…
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Modeling and Miniaturization: Key Topics at Successful HTPD Conference
…n high-throughput automated minibioreactor systems improved development timelines and the quality of scale-down models.
However, conference attendees said in a survey that the presentation they c…
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Advanced Technologies Facilitate Scale-up and Technology Transfer
The use of scale-down modeling, in which a large-scale system is reverse-engineered down to the lab scale so that it can be operated to model the large-scale process, has also significantly reduced th…