Search results for " monoclonal antibody"

Article Comparing Protein A Resins for Monoclonal Antibody Purification
With greater economic pressure on monoclonal antibody (mAb) production for therapeutic and research uses, antibody titers in mammalian cell culture have increased dramatically over the past 20 years. …

Article Evolution of the Monoclonal Antibody Purification Platform
Traditional Monoclonal Antibody Platform Figure 1 illustrates the traditional mAb platform that is commonly used (2,3). Typical steps include: • Protein A chromatography for capture of…

Article USP Publishes Monoclonal Antibody Guidelines
USP standards for mAbs Currently, licensed monoclonal antibody (mAb) therapeutics include those involved in the activation of effector cells, cell killing, cross-linked induced apoptosis, antagonis…

Article A platform approach for the purification of antibody fragments (Fabs)
This Application note describes a three-step purification process of a Fab originating from an E. coli supernatant. First, chromatography media (resins) were screened in 96-well P…

Article Impact of Media Components on CQAs of Monoclonal Antibodies
The authors review how media components modulate the quality of monoclonal antibody products.  By Anurag Rathore, Rajinder Kaur, Dipankar Borgayari  Recombinant protein products have…

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Article Antibody Fragments and Their Purification by Protein L Affinity Chromatography
Antibodies and related proteins comprise one of the largest and fastest-growing classes of protein pharmaceuticals. A majority of such molecules are monoclonal antibodies; however, many new entities…

Article Concentrating Feed—an Applicable Approach to Improve Antibody Production
In this study, the authors evaluated different approaches to prepare highly concentrated feed media for fed-batch Chinese hamster ovary cell culture. By raising the pH or by adding surfactants, the fe…

Article Achieving Greater Efficiency in the Production of Biosimilar Antibodies
The biosimilars market is set to reach more than US$20 billion in 2020 and both established biopharma and younger therapeutic manufacturers will play their part in meeting demand. Despite growing re…

Article EU Sets Guidelines for Biosimilar Monoclonal Antibodies
The European Union has reached an important stage in its efforts to make the region a biosimilars production center. The London based European Medicines Agency (EMA), which licenses EU pharmaceu…

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