Search results for " titers"

Multimedia Cell Culture Media Considerations and Optimization for Improved Titers and Protein Quality
Peggy Lio, Senior Director of Global Cell Culture Services at Cytiva, explores the evolution of bioprocessing over the last 30 years, parameters to consider when developing cell culture media, and wha…

Article Cell Culture Media Considerations and Optimization for Improved Titers and Protein Quality
Peggy Lio, Cytiva Peggy Lio, Senior Director of Global Cell Culture Services at Cytiva, explores the evolution of bioprocessing over the last 30 years, p…

Article Comparing Protein A Resins for Monoclonal Antibody Purification
With greater economic pressure on monoclonal antibody (mAb) production for therapeutic and research uses, antibody titers in mammalian cell culture have increased dramatically over the past 20 years. …

Article Generating a Fully Processed Antibody
…rotein needs to be produced at high enough levels to fully process all the biopharmaceutical at high titers without interfering with normal cell growth and the secretion of the molecule. Finally, som…

Article The Development and Application of a Monoclonal Antibody Purification Platform
…division, including how the individual unit operations have been affected by increasing cell culture titers and subsequent changes in the impurity profile, as well as viral clearance issues. The plat…

Article Gene Therapies Push Viral Vector Production
This makes it relatively straightforward to achieve desired titers and to achieve a single integration element, Carstens emphasizes. Downsides include the fact that it is more difficult to achieve lar…

Article Concentrating Feed—an Applicable Approach to Improve Antibody Production
There was no precipitation observed and antibody titers were not affected. These data show that concentrating feed medium either by raising pH or adding surfactant is an effective and applicable appro…

Article Technology Innovations Improve Process Chromatography Performance
Perfusion titers will increase over time like batch processes have previously. This will create a need for downstream process improvements that are being developed today,” Scanlon adds. Continuous…

Article Challenges in Cell Harvesting Prompt Enhancements
The past decade has seen the biopharmaceutical industry move toward significantly higher titers, and, as a result, higher cell densities. Biomanufacturers have been shifting from large stainless-steel…

Article Optimizing Late-Stage and Commercial Cell-Culture Processes
In the early 1990s, cell titers for monoclonal antibodies (mAbs) were in the range of 50–100 mg/L, notes Dr. Andy Racher, associate director future technologies, Lonza Pharma & Biotech. Today, however…

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