Search results for "CIP"
Article
Evaluating Surface Cleanliness Using a Risk-Based Approach
For automated clean-out-of-place (COP) and clean-in-place (CIP) applications, it is important to review coverage and flow velocity in vessels and piping, drainability of the wash and rinse solutions, …
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Hybrid Bioprocessing: A Q&A with Andrew Sinclair
Removing clean-in-place (CIP) and sanitization-in-place (SIP) from the equipment are primary drivers for simplification, the reduction in size in vessels so that everything fits into single floor faci…
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Re-use of Protein A Resin: Fouling and Economics
While the base matrices and ligand densities for the MabSelect and MabSelect SuRe are identical, the latter provides greater stability under alkaline conditions used in clean-in-place (CIP) protocols.…
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Automating Bioprocesses
One of the most significant differences is that SUS do not require the clean-in-place (CIP) and sterilize-in-place (SIP) systems employed in stainless-steel equipment systems, which saves initial capi…
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Comparing Protein A Resins for Monoclonal Antibody Purification
In addition, Protein A resins with the ability to withstand repeated cleaning-in-place (CIP) with low-cost sodium hydroxide (NaOH) considerably improves process economics.
Protein A Resins …
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Alkaline stability of Fc and VH3 binding in protein A resins
In this study, we have looked at how different antibody binding sites of a protein A ligand are affected by cleaning in place (CIP). We evaluated NaOH incubation and the effect of performed CIP cycles…
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Strategizing for Rapid Changeovers in Biologics Manufacturing
Other important facility design aspects for rapid changeover, according to Machulski, include: quality by design, design for manufacturability principles (i.e., lean, single-minute exchange of dies [S…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
These technologies provide several advantages over stainless-steel systems, including reduced capital investment, elimination of cleaning in place (CIP), and cleaning validation. These advantages, acc…
Article
Efficient Sodium Hydroxide Sanitization with a Novel Procedure of AxiChrom™ Columns Packed with Chromatography Resin
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Sodium hydroxide (NaOH) cleaning-in-place is the widely accepted method of sanitization employed by biopharmaceutical manufacturers to avoid the excessive costs and delays of a…
Resource
Protein A Fiber Chromatography from Research to Scale-up and Manufacturing of Monoclonal Antibodies
The new Protein A fiber chromatography format allows for quick purification of many samples because of its short cycle times. This makes the pre-packed, small-scale Protein A fiber unit a versatile …