Search results for "cell-culture"
Article
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
By Satish Mallya, Benjamin Lay, Lihong McAleer, Alexandria Emory, Nataliya Afonina
Abstract
Cell-culture media are essential raw materials that are required for the manufacture of biotherapeut…
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
Over the years, cell-culture processes have evolved to achieve optimum production yield and quality for both clinical development and commercial manufacturing.
Cell-culture evolution
Current c…
Article
Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
By Tom Fletcher, Holden Harris
Regulatory expectations for cell-culture-based biologics production processes changed dramatically once it was discovered in 1996 that a fatal disease (variant Creut…
Article
Cell-Culture Advances Test Bioreactor Performance Models
The continual development of higher-producing cell lines, the switch to chemically defined media, and other advances in cell-culture technology are, however, challenging developers of modeling and sim…
Article
QbD Improves Cell-Culture Process Control
QbD Improves Cell-Culture Process Control
A quality-by-design approach that implements PAT offers advantages in upstream cell-culture processing.
By Feliza Mirasol
Mar…
Article
Automated harvesting and 2-step purification of unclarified mammalian cell-culture broths containing antibodies
We report on a new integrated platform for automated harvesting of whole unclarified cell-culture broths, followed by in-line tandem affinity-capture, pH neutralization and size-exclusion chromatograp…
Webcast
Controlling Cell-Culture Process Variability
That is why we created a transparent, multi-source supplier network for cell-culture materials.
Article
Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
Complete removal of TBPP is not necessary, as many single-use bags containing TBPP perform well in cell-culture applications (11). By optimizing the level of TBPP in the formulation, both polymer degr…
Article
A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
Mid-phase assessment includes further characterization of the integrity and stability of the integrated transgenes using the defined commercial cell-culture processes. Finally, the presented strategy …
Article
Platform Approach Speeds Process Development
The platform includes vector design, cell line engineering, high-throughput screening by automation, systematic design of experiment (DoE)-based approaches for media and cell-culture process developme…