Search results for "doe"
Article
DoE Provides Benefits, but Preparation Is Necessary
28-29
Using a design-of-experiment (DoE) approach allows a formulation development scientist to examine the formulation design space in a statistically significant manner from the beginning of ex…
Article
Determining Criticality, Part Two: DoE and Data-Driven Criticality
A staged design of experiment approach
The following is an example of a simple staged design of experiment (DOE) approach. More complex DOE designs and strategies may be required, but these desi…
Article
How to program, run and evaluate a design of experiments (DoE)
Martin Sichting, Product Manager Lab Scale Chromatography Systems at Cytiva, guides you through the DoE process.
You’ll learn how to program, run, and evaluate a design of experiments (DoE) run. An…
Article
Benefits of DoE vs mechanistic modeling
Hear about the main differences between mechanistic modeling and design of experiments when used during chromatography process development. You will learn that, quite often, these methods work…
Poster
Development of DoE based fed-batch strategies for high-producing CHO cell cultures
Fed-batch culture is commonly employed to maximize cell and product concentrations in upstream mammalian cell culture processes. Typical standard platform processes rely on fixed-volume bolus feedin…
Article
Design of Experiments for Analytical Method Development and Validation
Design of experiments (DOE) is a well-proven characterization approach within product and process development and a key aspect of quality by design. Recently, more attention has been placed on applyin…
Article
Mechanistic Modeling: Does it Have a Future in Process Development?
Mechanistic models are considered as an alternative to a standard DoE type empiric approach. Most often, the DoE approach is preferred based on a cost-benefit evaluation where the time consumption, co…
Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Leveraging the power of HTPD and DoE for chromatographic optimization
The goal in HTPD is to evaluate numerous factors or conditions in parallel using micro-scale formats. It reduces experimental …
Article
Handbook: Design of Experiments in Protein Production and Purification
In a protein research lab or during process development, a DoE approach can greatly improve the ef ciency in screening for suitable experimental conditions, for example, for cell culture, protein sepa…
Article
Robust Optimization, Simulation, and Effective Design Space
Design of experiments (DOE) and other multivariate analysis techniques assist the developer in mapping out the design space and building process models. Once the DOE is complete, the developer can use…