Search results for "modeling"
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
For complex unit operations such as process chromatography, mechanistic modeling can assist in developing a systematic approach for process development, monitoring, and control. Models can also be jud…
Article
Modeling Bioreactor Performance
Modeling of bioprocesses is an essential tool when determining the best bioreactor for a new process, when moving a process from one type of bioreactor to another (e.g., stainless steel to single use)…
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Cell-Culture Advances Test Bioreactor Performance Models
Challener
Modeling and simulation are recognized to provide assistance in predicting bioreactor performance, both for initial laboratory runs and when scaling to the pilot plant and commercial ma…
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Leveraging Computational Models of Glycosylation for Biopharma QA
This review focuses on how different modeling strategies can be leveraged to aid in product QA across the different stages of biopharmaceutical product development and manufacture. Technical details o…
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Modeling the Degradation of mAb Therapeutics
Kinetic modeling can be an effective tool for establishing product stability, offering a deeper understanding of these processes and allowing developers to mitigate the risk of product degradation dur…
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The Need for Advanced Process Modeling for New Therapeutic Biologics
The trend toward personalized medicines includes more complex manufacturing cycles that can benefit from advanced process modeling early on in the therapeutics’ development.
By Feli…
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Mechanistic Modeling: Does it Have a Future in Process Development?
…n, complexity, and lack of know-how on how to deploy are found too extensive when using mechanistic modeling. Novo Nordisk uses mechanistic models for the development of selected downstream process s…
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Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
This week, Bioprocess Development Forum spoke with Tobias Hahn, PhD, co-founder and CEO of GoSilico, about the opportunities of mechanistic modeling in bioprocess development, now and in the future.
…
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Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
Topics covered include:
0:45 - What is mechanistic modeling of chromatography?
3:47 - Obstacles to implementing mechanistic modelling.
5:10 - Top tips for implementing mechanistic modeling…
Article
Using Digital Twins to Model Process Chromatography
Benefits and challenges in digital twins for biopharmaceutical manufacturing
BioPharm: Are digital twins typically used for modeling individual unit operations in biopharmaceutical manufacturing? …