October 8, 2015

E. coli growth and Dab expression in single-use and stainless steel fermentors

This application note describes the performance of the Xcellerex™ single-use XDR-50 MO stirred-tank fermentor in an E. coli domain antibody (Dab) production process  developed for a stainless steel fermentor. Cell growth,
cell density, and Dab expression levels were assessed and compared between the two production vessels. The  results show that the performance of the XDR-50 MO fermentor is comparable with that of the reference stainless steel fermentor.

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Tags: bioreactor, fermentor, E coli, domain antibody, dAb, single-use