March 27, 2023

Efficient chromatography buffer prep with inline dilution

A typical bioprocess workflow requires many buffers and process liquids in large volumes, making buffer preparation one of the most resource-intensive activities in biomanufacturing facilities. 

Here, we discuss the accuracy and performance of the inline dilution (ILD) technology found in the AKTA process™ chromatography system. We also compare the process economy of ILD versus manual buffer preparation — which is still the most common way to prepare buffers — by looking at the labor time, buffer volumes, floor space, and required investments for each approach.

Tags: Buffer prep, buffer preparation, buffer management, chromatography, inline dilution, ILD, ÄKTA process