March 1, 2018

Efficient Cleaning-In-Place Methods for Protein-Based Antibody Affinity Chromatography Resins

resin cleaningThis whitepaper discusses cleaning of affinity resins intended for use in the purification of monoclonal antibodies and antibody fragments, for example, Fab fragments. Various cleaning strategies and the impact of different cleaning agents and concentrations on the resin lifetime are presented. As the use of sodium hydroxide (NaOH) is considered standard in the bioprocessing industry, the impact of treatment of affinity resins with various concentrations of this cleaning agent is demonstrated

Read the white paper here. 

Tags: antibody fragments Image: Resin cleaning, protein L, cleaning in place, Mab, Protein A, affinity chromatography