February 9, 2024

Selecting Chromatography Resins for Bispecific Antibody Purification

Targeting enhancement with two active antibody arms makes bispecific antibodies (bsAbs) highly attractive for the treatment of cancer and other diseases. Their purification can be more challenging than traditional monoclonal antibodies (mAbs), however, due to the increased level of product-related impurities with high similarity to the desired bsAbs. Advances in chromatography resins are helping to simplify downstream operations and improve separation performance.


Tags: process development, purification, Mab, monoclonal antibody formulation, Mab purification, antibody therapy, resin, antibody characterization