January 14, 2021

What If You Could Remove Your Antibody Aggregates Already in the Protein A Step?

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In this study, the potential of Protein A chromatography to separate antibody monomer from HMW species was investigated. A design of experiments approach was used to study the influence of four factors on the removal of HMW species: (1) elution buffer type, (2) conductivity of the elution buffer, (3) pH gradient length and (4) Protein A resin type.

Tags: mAb purification, Protein A resin, Aggregate removal, purification performance