September 13, 2018

A Scalable Adenovirus Production Process

The promising results from clinical studies on the use of viral vectors to address important medical needs have spurred interest in developing scalable and cost-efficient manufacturing processes. To meet these needs, a process for adenovirus production, from upstream cell culture to downstream purification, using modern tools and technologies was developed.

The novel process is easily scaled and compatible with both single-use and steamable hard-piped process equipment. The process has process economical advantages compared with an existing reference process and includes new technologies and convenient and sensitive virus titer assays.

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