Search results for " buffer preparation"
Article
Process Chromatography Selection for Downstream Processing Applications
Industry experts discuss best practices for selecting a separation technology.
By Caroline Hroncich
Process chromatography has changed significantly since it was first introduced to the biop…
Article
Implementing Inline Conditioning to Advance Process Intensification
…from manual preparation of buffers to implementing inline conditioning (IC) technology for automated buffer preparation.
What were the main drivers to evaluate a new technology and move from trad…
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Improving Process-Scale Chromatography
She adds that Cytiva’s IC skid requires less space than ILD and also addresses issues with buffer variability by allowing for feedback control of the buffer preparation process. “Dynamic control caref…
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HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
Some improvements have been made to decrease the development time of IEC, such as the development of a quaternary solvent system to simultaneously adjust the pH and salt concentration to reduce buffer…
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What’s New in Upstream Technologies
The platform is an integrated solution for more efficient buffer delivery that is tailored to provide a high level of accuracy and precision in buffer preparation and management. According to Millipor…
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QbD and PAT in Upstream and Downstream Processing
To gain perspective on the implementation of quality by design (QbD) and process analytical technology (PAT) in biopharmaceutical processing, BioPharm International spoke with Clinton Weber, as…
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Development of Purification for Challenging Fc-Fusion Proteins
Development of Purification for Challenging Fc-Fusion Proteins
This study outlines methods for an alternative protein-polishing process for challenging proteins.
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Preclinical Evaluation of Product Related Impurities and Variants
Preclinical Evaluation of Product Related Impurities and Variants
The approaches for sample preparation of preclinical evaluation of safety and efficacy are addressed taking into consideration the s…
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From Darwin to Recombinant Fc Multimers
Topics from a Darwinistic viewpoint on how business models are evolving in the Life Science industry to breakthrough research data from Momenta Pharmaceuticals on a recombinant trivalent Fc protein …
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Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
The buffer preparation schedule for downstream purification can have a significant impact on facility design. Whether it is just-in-time preparation, one day in advance of use, or before any purificat…