Search results for "CIP"
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Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
This week Process Development Forum talks about Protein A with Jonathan Royce, business leader for Cytiva chromatography resins.
mAb purification platforms are very well established, and …
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Bioburden Control in the Biopharmaceutical Industry
Appropriate clean-in-place (CIP) and sterilization-in-place (SIP) operations should be performed strictly for all lines within specified conditions. Sterilization filters with associated pre-filters s…
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The New World of Biopharmaceutical Manufacturing
Single-use technology has also precipitated changes in upstream and downstream processing.
Pharmaceutical Technology spoke with Eric Langer, managing partner at BioPlan Associates; John …
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Improving Process-Scale Chromatography
In principle, according to Ljungqvist, it is possible to purify mAbs using any chromatographic technique, but it is difficult to achieve a similar purity, robustness, and as high a yield as generally …
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Process Chromatography Selection for Downstream Processing Applications
BioPharm: What are some new separation technologies available for downstream processing?
Becerra-Arteaga (MilliporeSigma): In the harvest steps, the use of precipitation and flocculation technique…
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Developing Cleaning-in-Place Protocols
Cleaning conditions for chromatography media can be screened in a couple of working days using 96-well microtitre plate formats. A study with a Protein A resin illustrates the approach in this appli…
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Fluid Handling in Biopharma Facilities
Particularly, less investments in clean in place and sterilize in place (CIP/SIP) and automation infrastructure are main drivers. For nonsterile fluids, this major point is not important. In addition,…
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Cleaning of Dedicated Equipment: Why Validation is Needed
This article discusses cleaning validation of equipment dedicated to the production of a single API.
By Cristina Baccarelli, Paola Bernard, Teresa Cortellino, Oscar Cruciani, Rita Pacello, Chi…
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Trends in Single-use Bioreactors
Participating in the roundtable are Jacob McNeil, senior product manager, single-use bioreactors at Thermo Fisher Scientific; Warren Ang, product manager, bioprocess at Eppendorf; Parrish Galliher, fo…
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Evolution of the Monoclonal Antibody Purification Platform
Apart from the relative high cost of the resin, it has limited binding capacity and issues with clean-in-place (CIP) with sodium hydroxide. The alternative can be cation exchangers or hydrophobic char…