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Cell Culture Media Considerations and Optimization for Improved Titers and Protein Quality
Peggy Lio, Senior Director of Global Cell Culture Services at Cytiva, explores the evolution of bioprocessing over the last 30 years, parameters to consider when developing cell culture media, and wha…
Article
Cell Culture Media Considerations and Optimization for Improved Titers and Protein Quality
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Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
In the first step, optimal feed combinations were screened by spiking the basal medium with different Cell Boost combination on day 0 of batch cultures. The selected Cell Boost supplements were therea…
Poster
Strategies for optimized cell culture media: Effectively using design space to influence product quality
Here we highlight a statistical design strategy to optimize cell culture media to influence the charge variant profile of a mAb produced in CHO DG44 cells.
Media optimization requires incorp…
Poster
Scale-up of CHO fed-batch cultures in HyClone™ ActiPro™ medium supplemented with Cell Boost™ 7a and 7b
Results from shake flask cultures show high viable cell densities and protein production. In addition, scalability of the culture process was demonstrated in 2 and 50 L bioreactor cultures. Cell densi…
Webcast
Trace metals getting you down? Learn what’s really in your cell culture media with Cytiva.
Heavy metal impurities in your media can have a drastic effect on cell viability, with some impurities reducing cell culture density by as much as 17x. So, how can you be sure these impurities are con…
Article
Trace metals getting you down? Learn what’s really in your cell culture media
Heavy metal impurities in your media can have a drastic effect on cell viability, with some impurities reducing cell culture density by as much as 17x. So, how can you be sure these impurities are con…
Webcast
Establishing a CHO-K1 cell line and cell line development process for biotherapeutics markets
But how can you meet rapid timelines when the cell line development workflow is challenged by documentation needs, commercial use rights, and regulatory scrutiny?
Join Cytiva’s webinar on February…
Article
Perfusion Culture Using TFF or ATF as Cell Retention Method
Compared with batch or fed-batch processes, perfusion processes also allow cells to be maintained in exponential growth phase for an extended period of time and reach higher viable cell densities.
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Poster
Effects of feeding strategy on CHO cell performance in fed-batch cultures
This work demonstrates the development of a fed-batch process for a Chinese hamster ovary (CHO) cell line producing a monoclonal antibody (mAb). The results emphasize the importance of an appropriate …