Search results for " single-use systems"
Article
Single-Use Workflow for Recovery of a Domain Antibody from E. coli Culture Feed in an Automated Manner
This application note demonstrates the performance of the automated ÄKTA™ readyflux single-use filtration system in microfiltration applications. Here, a domain antibody (dAb) expressed in E. col…
Article
Single-Use Extractables and Leachables: Cytiva's Alignment with the BPOG Protocol
Despite years of discussion and experience, E&L testing approaches for single-use equipment have not yet fully matured into a consensus industry practice. Copious amounts of data have been generated…
Article
The New World of Biopharmaceutical Manufacturing
Single-use technologies
PharmTech: What have been the most significant advances in single-use systems for biopharmaceutical manufacturing in the past 40 years?
Langer (BioPlan As…
Article
A Plastic Pipeline for Commercial Bioprocessing?
…steps and cleaning validation, and a lower risk of cross contamination are recognized as benefits of single-use systems compared with traditional stainless steel (2).
Business strategies and p…
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Reducing Cross-Contamination Risks in Process Chromatography
Hybrid solutions
With single-use systems providing advantages for some, but not all, process chromatography applications, often biopharmaceutical manufacturers use hybrid solutions that incorp…
Article
Modular Manufacturing Platforms for Biologics
The addition of single-use systems reduces turnover and allows for more flexibility in production planning. With single-use systems, “The changeover to another product can be swift, and potential cros…
Article
Setting Up Bioprocessing Systems for Digital Transformation
Single-use systems risks
The same principles and need for data integrity apply to single-use systems but at a higher volume, says Lenich. He emphasizes that, in addition to maintaining data integr…
Article
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
Solid or hydrated buffers and salts that come ready-to-dispense in single-use bags and buffer preparation using single-use systems, reactors, and in-line dilution can both help eliminate or reduce wei…
Article
Advanced Technologies Facilitate Scale-up and Technology Transfer
As a result, a reactor for mammalian cell culture is not required to have high heat removal or provision for high oxygen supply; as such, single-use systems are well suited.
The situation is diffe…
Article
Fluid Handling in Biopharma Facilities
Facility layout can help determine how companies handle fluid transfer and storage, and increased use of modular facilities and single-use systems (SUS) in the production and transfer of sterile fluid…