Search results for " capacity" in Articles / App Notes
Article
Re-use of Protein A Resin: Fouling and Economics
It has been shown that the extended use of a resin results in decrease in its binding capacity, a decrease in product recovery, and a loss of Protein A ligands (9). Recent innovations in Protein A-aff…
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
…), and vendors of mAb purification technologies must develop chromatography resins with high binding capacity to meet the demand. In addition, more cost-efficient cleaning procedures are necessary to…
Article
The Outlook for CMO Outsourcing in 2019
Routine services and products with smaller markets will be outsourced more frequently, and products requiring novel bioprocessing, where expertise or capacity remain limited, will also be outsourced m…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
Need for higher commercial capacity
Many viral-vector manufacturing processes for gene therapies were initially developed in academic laboratories using traditional plasticware systems such as m…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
Becker points out that currently there is only limited global capacity for biopharma production, some of which is required for existing drug and vaccine products. In addition, both traditional and gen…
Article
The Challenge of Disruptive Technologies in Bioprocessing
Thermo Fisher Scientific aims to address this challenge with a series of commercialized hydrophobic interaction chromatography resins with a differentiating range of hydrophobicity, resolution, high c…
Article
Contract Manufacturing Through the Years
The first was the shedding of excess capacity by global bio/pharmaceutical companies as older products went off patent and as the establishment of the European Union and North American Free Trade Agre…
Article
Process Chromatography Selection for Downstream Processing Applications
…ecipitation and flocculation techniques has recently proven to be an alternative for improved filter capacity in the clarification of high cell density cultures, as well as a means of reducing some p…
Article
Challenges and Trends in Biopharma Facility Design
The ability to produce more than one biomolecule, for example by incorporating single-use capacity, supports smaller-batch production of ‘niche’ medicines. Adapting legacy facilities to this more flex…
Article
The Development and Application of a Monoclonal Antibody Purification Platform
This increased the loading capacity of this step by a factor of up to 100. All other unit operations remained the same. The resulting process is shown in Figure 1 as process 3.
Then, the timeline …