Search results for " mixing"
Article
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
This process requires proper recording and tracking of buffer component kits until the subdivided materials can be dispensed into a single-use or stainless-steel mixing vessel according to the specifi…
Article
Improving Upstream Predictability
“Significantly higher cell densities will result in challenges with respect to mixing and oxygen transfer, while new modalities such as cell and gene therapies will require innovation,” he says.
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Article
Fortem: One Film for Single-Use Bioprocessing
Single-use bags can now be found at every stage of bioprocessing: bioreactor and mixing systems, harvest and collection, purification, and liquid and powder storage and transportation. Thus, Cytiva ha…
Article
Design Considerations for a Commercial Cell and Gene Therapy Facility
The commercialization of cell and gene therapies has become a reality, prompting deeper considerations of logistics, technology, and design for manufacturing facilities.
By Feliza Mirasol
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Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use technology is gaining ground in downstream bioprocessing, but challenges stall further adoption.
By Feliza Mirasol
ARTMOIS/STOCK.ADOBE.COM
Biopharmaceutical manufactu…
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
A major advantage of SPR-based analysis is its ability to estimate the association and dissociation rate constants, an …
Article
Modeling the Degradation of mAb Therapeutics
Environmental factors that can have an impact on the protein include pH, temperature, salt concentration, buffer type, protein concentration, ionic strength, mixing, shear, metal ions, pressure, freez…
Article
The Outlook for CMO Outsourcing in 2019
By Eric Langer and Ronald A. Rader
Biopharmaceutical industry-related indicators and trends are supporting continued incremental increases in outsourcing of pre- and commercial AP…
Article
Achieving Process Balance with Perfusion Bioreactors
single use
Long process durations, high oxygen transfer rates, and short mixing times are not a challenge for quality stainless-steel bioreactors equipped with double mechanical seals or magnetic …
Article
Scaling Up Novel Therapies
“Challenges tend to come with scale-dependent parameters that are more difficult to mimic, such as mixing, heat transfer, and mass transfer,” he says.
High throughput
There is still a…