Search results for " MabSelect" in Articles / App Notes
Article
Sanitization Opportunities for Protein A Resins
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Bacterial endospores present a challenge in bioproduction due to their resistance to common sanitization procedures using high concentrations of NaOH. Several protein-b…
Article
Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
The process, performed with MabSelect™ PrismA Protein A chromatography resin, was scaled up 20-fold from a 70 mL HiScale™ 26 column to a 1400 mL AxiChrom™ 100 column. Equivalent mAb recovery and purit…
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Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Several years ago, we started a development project to design and validate the next-generation protein A resin, MabSelect PrismA, which was just introduced to the market. Now, 1M NaOH can in fact be u…
Article
Top challenges in recombinant protein purification process development
…ent from mAbs, which do have a great affinity solution that can be used in protein A, such as Cytiva MabSelect PrismA. But then there's also a good platform approach that can be used. So after your a…
Article
Optimization of a two-step purification method for bispecific antibodies
Bispecific antibodies (bsAbs) have gained increasing interest over recent years because they can bind two antigens, offering unique modes of action compared to monoclonal antibodies. New and i…
Article
Capture of Bispecific Antibodies and Removal of Product-Related Impurities
In this article, Cytiva presents data on applications using MabSelect™ VL protein L resin with novel selectivity to purify challenging entities.
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Article
Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator Bioscience AB develops antibody-based pharmaceuticals for cancer treatment, specializing in mono- and bispecific antibodies for tumor-directed immunotherapies. Alligator and Cytiva devel…
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Cytiva Advances Fiber Chromatography Technology with New Launch
Using Ology Bio’s mAb platform, we have gained two orders of magnitude greater productivity using Fibro PrismA than MabSelect PrismA resin,” said Ryan Davis, senior scientist at Ology Biosciences, in …
Article
Developing a Closed, Connected Single-Use mAb Purification Process
In the Protein A step, Fibro PrismA is compared with MabSelect PrismA regarding process time, recovery, and purification performance.
Article
Cytiva Invests $500 Million Over 5 Years to Expand Global Capacity
The manufacturing capacity of Cytiva's MabSelect and Capto chromatography product platforms has also doubled as part of a $70-million-per-year (2017–2022) investment in capacity gains and a facility m…