Search results for "monoclonal antibodies"
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Evolution of the Monoclonal Antibody Purification Platform
Monoclonal antibodies (mAb) increasingly form the majority share of the product pipeline, as well as revenue, of major biopharmaceutical companies (1). What is unique about mAbs from a processing pers…
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USP Publishes Monoclonal Antibody Guidelines
…Pharmacopeia (USP) General Chapter “Analytical Procedures for Recombinant Therapeutic Monoclonal Antibodies,” which is set to become official in USP’s compendia of standards, USP 39–National Formula…
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Top Tips for Successful Development of Antibody Chromatography Processes
If we look back a couple of years, we saw that the main antibody group was monoclonal antibodies. But today, it's a lot more diverse. We see more fragments, such as Fabs, scFv fusion proteins, domain …
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FDA Provides Guidance on Bispecific Antibody Development Programs
… products but does not discuss antibody cocktails, polyclonal antibody products, or combinations of monoclonal antibodies.
Source: FDA
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eBook: Purification of Antibody Therapeutics - Approach for Diversified Pipeline
Over the years, development beyond traditional monoclonal antibodies (mAbs) has increased. Today, we see multispecific and bispecific antibodies, antibody fragments, and antibody drug conjugates in th…
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Impact of Media Components on CQAs of Monoclonal Antibodies
The authors review how media components modulate the quality of monoclonal antibody products.
By Anurag Rathore, Rajinder Kaur, Dipankar Borgayari
Recombinant protein products have…
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Antibody Fragments and Their Purification by Protein L Affinity Chromatography
A majority of such molecules are monoclonal antibodies; however, many new entities are antibody fragments. Due to their structural, physiological, and pharmacological properties, antibody fragments of…
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Concentrating Feed—an Applicable Approach to Improve Antibody Production
Three recombinant Chinese hamster ovary (CHO) cell lines, developed in-house to produce three different monoclonal antibodies, were used in this study. Cell lines A and B are dihydrofolate reductase-d…
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Guide for selecting affinity resins for mAbs, bsAbs, and antibody fragments
Development of antibody-derived molecules are increasing. Today, molecules such as bispecific antibody (bsAb) and antibody fragments such as Fab, scFv, and VHH are seen in labs all over the w…
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Optimization of a two-step purification method for bispecific antibodies
Bispecific antibodies (bsAbs) have gained increasing interest over recent years because they can bind two antigens, offering unique modes of action compared to monoclonal antibodies. New and i…