Search results for " modeling"
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
Read full article>>
As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quic…
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
Click here to learn more >>
We have developed a reliable small-scale model for a monoclonal antibody (mAb) perfusion process using TPP® TubeSpin® Bioreactor tubes and the ReadyToProcess WAVE 25 R…
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAb at Large Scale
Click here to read more >>
As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quick…
Article
Cytiva and GoSilico Agree to Co-market ChromX™ Mechanistic Modeling Software
The agreement facilitates the adoption of ChromX™ by scientists and users of resins, columns, and chromatography systems into their downstream process-development workflows to accelerate development…
Article
Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
READ ARTICLE >>
In process development, it is desirable to test process parameters in small scale and later scale up the process into larger production scale. A theoretical scale-up study was per…
Article
Going Small to Achieve Success on the Commercial Scale
He adds that timing and planning of modeling runs is also important and can negatively influence results if not done effectively. For example, it is important to use the same feed used for production …
Article
Digitalization: The Route to Biopharma 4.0
Recently, a hybrid modeling approach, combining both mechanistic modeling and data-driven modeling, has been shown to offer a multitude of benefits. For chromatography, relating data from sensor with …
Article
Determining Criticality, Part Two: DoE and Data-Driven Criticality
…th fermentors of 5000 to 25,000 L), hence, most biotech process development programs rely heavily on modeling the process at smaller or intermediate scale. Some process parameters may be independent …
Article
Discovering the unknown: How does in silico process development change PD scientists’ work?
But what does it actually mean to perform process development in silico? Do I need to be a math expert? Where is modeling applicable? Will I not set foot in the lab ever again?
Transcript
…
Article
Report from the 6th International HTPD Conference
A preconference day focused on getting up to speed with mechanistic modeling
This year, the week started with a pre-conference day about mechanistic chromatography modeling, organized by Cyt…