Search results for " multimodal" in Articles / App Notes

Article Enhancing Resins Addresses Purification Concerns
Christoph Burgstedt/Stock.Adobe.com Enhancement of resin technology can improve the ability of chromatography to purify the growing landscape of increasingly complex biomolecu…

Article Technology Innovations Improve Process Chromatography Performance
As technology matures, inefficiencies and process limitations in downstream process chromatography are improved. By Feliza Mirasol Selecting an appropriate separation technology fo…

Article Addressing the Complex Nature of Downstream Processing with QbD
It is therefore common to reduce aggregate content to below a threshold value using cation exchange, multimodal chromatography, or hydrophobic interaction chromatography. For this kind of step, it is …

Article A Look at the Affinity Chromatography Landscape
He does note that the use of standard and multimodal resins and high-throughput screening technologies greatly aid in defining separation techniques. Most importantly, Heldin adds that affinity…

Article Tools and Solutions for Separation of Charged mAb Variants
A biosimilar is an almost identical version of an originator product. To attain regulatory approval, a comparable quality to the reference product in terms of efficacy, purity, and safety should be …

Article Preclinical Evaluation of Product Related Impurities and Variants
Preclinical Evaluation of Product Related Impurities and Variants The approaches for sample preparation of preclinical evaluation of safety and efficacy are addressed taking into consideration the s…

Article Continuous Processing for the Production of Biopharmaceuticals
The increased use of multimodal resins and single-use technologies can also play an important role in continuous operation. Individual efforts made by different researchers to make unit operations…

Article Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
… first polishing step with cation-exchange media, and a final polishing step using anion-exchange or multimodal media. Even this platform process requires some fine-tuning and adjustment for new mAb …

Article A Platform Approach for the Purification of Domain Antibodies (Dabs)
This Application note describes a three-step purification process of a domain antibody (Dab) expressed in the periplasm of E. coli. First, a capture step using Capto™ L was used to reduce E. coli host…

Article Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The multimodal function of the chromatography medium, utilizing both size exclusion and affinity binding, reduces the number of purification steps needed by combining two procedures in one. The proper…

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